Megakaryocytic blast crisis in chronic myeloid leukiemia: An uncommon presentation in a common neoplasm

Megakaryocytic blast crisis at presentation in a pediatric patient with chronic myeloid leukemia.

Patients with chronic myeloid leukemia (CML) infrequently present in blast crisis (BC). While most BC are of myeloid origin, megakaryocytic BC is rare, especially at the time of CML diagnosis. We describe the first pediatric patient presenting with megakaryocytic leukemia and having BCR-ABL1 translocation as the single chromosomal abnormality. Clinical features were more suggestive of CML in me...

A case of chronic myeloid leukaemia presenting as megakaryocytic blast crisis (AML M7)

Acute megakaryocytic leukaemia (AMeL) is a rare subtype of acute myeloid leukaemia, which can be frequently misdiagnosed as acute myelofibrosis or myelosclerosis [1]. Chronic myeloid leukaemia (CML) presenting primarily as megakaryocytic blast crisis is very rare, with very few case reports published to date [2, 3]. This case report describes a 36-year-old woman who presented with anaemia and m...

Erythroid blast crisis of chronic myeloid leukemia.

70-year old woman was admitted with a diagnosis of pyelonephritis. The physical examination showed her to be lethargic and febrile (39°C). There was no liver or spleen enlargement. Laboratory findings were as follows: white blood cell count: 25310, hemoglobin level: 11.2 g/dL, platelet count: 41310/L, lacticodehydrogenase level: 4,100 IU/L (normal value < 350); erythrocyte sedimentation rate: 9...

Vulvar fibroadenoma: a common neoplasm in an uncommon site

Vulvar fibroadenomas are sporadic lesions informed in the literature and a controversy about origin has been discussed widely. We report a case of a 19 years old woman with a large slow growing mass in the right labia majora with the final diagnosis of fibroadenoma with mammary tissue surrounding it and positive hormone receptors. In this case, we support the origin in ectopic mammary tissue.

An uncommon presentation of a common cancer.